A hope against the disease? Brain changes identified 20 years before Alzheimer's diagnosis


By CAPosts 26 November, 2020 - 10:00pm 72 views

Alzheimer's is a disease that has been the subject of various studies and scientific treatments in order to counteract it, therefore, the brain changes 20 years before the diagnosis of the disease that researchers from the Sant Pau Hospital in Barcelona have identified, are a hope.

© Provided by Milenio The study has applied a new magnetic resonance technique developed in a hospital in Barcelona. (Shutterstock)

This research, published in the journal Alzheimer's & Dementia: The journal of the Alzheimer's Association and involving more than 300 patients , has detected brain changes in healthy people who are carriers of genetic alterations that cause Alzheimer's at an age precocious and still without clinical symptoms that would be indicators of the onset of the disease

The study has applied a new magnetic resonance technique developed at Hospital Sant Pau that allows to measure the movement of water in the brain and with it they have been able to estimate in what At the time of their life, the participants would develop the first clinical symptoms of the disease

The research, in which the Alzheimer's and other cognitive disorders Unit of the Hospital Clínic-Idibaps and researchers from the global consortium The Dominantly Inherited Alzheimer Network (DIAN) have collaborated , has verified changes in the cerebral cortex about 20 years before the first alterations appear and n memory

© Provided by Milenio

Engineer Víctor Montal, first author of the work, explained that, thanks to developing new neuroimaging modalities and proper statistical modeling, they have been able to better study the subtle changes related to Alzheimer's disease, that "allow a better understanding of the disease, studying the trajectory of these alterations long before the clinical symptoms appear ".

The work has studied the trajectories of more than 300 participants, in whom, due to a known mutation in their genome, have been able to estimate at what point in their life they would develop the first clinical symptoms of Alzheimer's.

According to neurologist Juan Fortea, principal investigator of the project, "the new data obtained will have a great implication when designing future studies to understand unexpected findings of clinical trials with antiamyloid therapies ".


Source: MSN