AstraZeneca antibody cocktail study shows success treating COVID-19 | Toronto Sun torontosun.com/news/world/astrazeneca-antibody-cocktail-succeeds-in-late-stage-study-to-treat-covid-19
Shad Home Sec Nick Thomas-Symonds: “reported infiltration of security around AZ Covid vaccine shows the extent of the danger the Russian state poses to Britain.. Home Sec must take responsibility and come before Parli to set out the nature and implications of this serious breach"
Merck seeks authorization for what would be first pill to treat COVID-19, and AstraZeneca reports positive results for antibody treatment www.marketwatch.com/story/merck-seeks-authorization-for-what-would-be-first-pill-to-treat-covid-19-and-astrazeneca-reports-positive-results-for-antibody-treatment-11633963392?reflink=mw_share_twitter
Russian spy 'stole AstraZeneca vaccine blueprint and used it to develop Sputnik jab' www.independent.co.uk/news/world/europe/russia-astrazeneca-vaccine-blueprint-sputnik-b1935992.html
11 October, 2021 - 09:13pm
The drug, called AZD7442, is a combination of two antibodies given as an injection.
AstraZeneca said it's the only drug of its kind shown to both prevent and treat COVID-19.
AstraZeneca's antibody drug cut the risk of severe COVID-19 by at least 50% in a late stage study, the company announced on Monday.
The injection, called AZD7442, contains two different antibodies developed from the the blood of people who previously contracted COVID-19. It's the first drug of its kind shown to both prevent and treat COVID-19 in late-stage trials, the company said in a press release.
The company has already requested Food and Drug Administration (FDA) approval to use AZD7442 to prevent COVID-19, after late-stage trial results in August showed it reduced the risk of COVID-19 with symptoms by 77%.
It would now discuss the latest data with health authorities, it said.
The latest AstraZeneca results, from the TACKLE trial, showed that the risk of severe COVID-19 or death was halved if people took the drug within seven days of COVID-19 symptoms, AstraZeneca said. Out of 407 people who got the drug, 18 developed severe COVID-19 or died - compared with 37 of 415 people who got a saline injection.
If AZD7442 was given earlier, within five days of symptoms, the risk of severe COVID-19 was reduced by 67%, the company said. On this timing, nine of 253 participants in the AZD7442 group got severe COVID-19 or died, compared with 27 out of 251 in the placebo group.
AstraZeneca tested the drug on 822 adults with mild to moderate COVID-19 in 13 countries, including the US and UK, it said. The drug, which works by stopping the virus that causes COVID-19 from binding to the body's cells, was "generally well tolerated," it said in the release. It didn't detail any side effects.
Mene Pangalos, executive vice president at AstraZeneca, said in a statement that "early intervention with our antibody can give a significant reduction in progression to severe disease, with continued protection for more than six months."
AstraZeneca looked at the drug's impact at day 29 of the TACKLE study, which is expected to follow participants for up to 15 months. AstraZeneca's early stage studies have previously shown that antibodies last at least nine months after the drug is given.
Penny Ward, visiting professor in pharmaceutical medicine at Kings College, London, said in a statement that long lasting protection, up to 12 months, may be "a useful addition for immune-suppressed individuals whose response to vaccination is suboptimal."
Most people in the trial, 90%, had comorbidities that put them at high risk of severe COVID-19, including cancer, diabetes, obesity, chronic lung disease or asthma, cardiovascular disease, or immunosuppression, and 13% were aged over 65, AstraZeneca said.
Ward said that unlike oral pills, monoclonal antibody treatments given as an injection, such as AstraZeneca's, don't interfere with other medicines. This "may potentially make administration simpler for these patients," she said.
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The European Medicines Agency (EMA) said on Monday it will assess the risks and benefits of the drug, called Ronapreve, and it could issue an opinion within two months. It belongs to a class of drugs called monoclonal antibodies that mimic natural antibodies produced by the body to fight off infections. The EMA said it was assessing clinical data investigating the effectiveness of the drug in preventing hospitalisation in outpatients, and another study looking at effectiveness in preventing COVID-19 in adults and children at risk of infection from a household member diagnosed with the disease.
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AstraZeneca said its experimental drug had helped cut the risk of severe disease or death in a late-stage study. * An AstraZeneca senior executive said the drugmaker's antibody cocktail would have a "real advantage" in preventing infection with the coronavirus compared with use as a treatment, after trials showed promise in both settings. * The European Union's drugs regulator is evaluating a marketing authorisation for an antibody cocktail developed by Roche and Regeneron for the treatment and prevention of COVID-19 in people above the age of 12.
GENEVA (Reuters) -The World Health Organization on Monday recommended that immunocompromised people be given an additional dose of COVID-19 vaccine, due to their higher risk of breakthrough infections after standard immunisation. The Strategic Advisory Group of Experts on immunisation said the additional dose should be offered "as part of an extended primary series since these individuals are less likely to respond adequately to vaccination following a standard primary vaccine series and are at high risk of severe COVID-19 disease". WHO vaccine director Kate O'Brien, referring to people with lower immunity due to other conditions, told a news briefing: "The recommendation is for a third vaccination, an additional vaccination in the primary series and again that is based on the evidence showing that the immunogenicity and evidence on breakthrough infections is highly disproportionately represented by those people."
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