UPDATE: We and @BioNTech_Group officially submitted our request to @US_FDA for Emergency Use Authorization (EUA) of our #COVID19 vaccine in children 5 to <12. pic.twitter.com/72Z2HXlkOx
Not recommending, but what would happen if the government required citizens to have any ONE of these three things to have full access to society? 1. Vaccination or... 2. Natural immunity or... 3. Pass a written test on COVID-19 risks
Over the past week, #Taiwan has received more than 3.4 million vaccine doses. As we gear up for our 2021 National Day Celebration, it is heartening to know that more Taiwanese will soon be vaccinated & better protected against COVID-19. pic.twitter.com/ExXjohZDLx
It’s Super Pfizer Weekend 2.0 👏 Families are getting vaccinated at our high school pop-up clinics. Thanks, Queensland 🙏 pic.twitter.com/p5qA85rQkp
Another Pfizer study from Israel showed neutralizing antibodies waning dramatically after 6 months.
But Pfizer's protection against severe disease and death is still well over 90% for at least 6 months.
People who get Pfizer's two-shot vaccine may still catch COVID-19 in the months after they are fully vaccinated - though those infections may be so mild they fly entirely under the radar.
Two new studies, published in the New England Journal of Medicine on Wednesday, show that Pfizer's mRNA shots still remain effective in guarding against hospitalization and death for at least six months, though protection against milder disease as well as antibody levels can fall - or at least they did in the face of the Beta and Delta variants.
The new findings affirm what Pfizer, Moderna, and the Centers for Disease Control and Prevention have indicated in recent weeks - that the mRNA vaccines' ability to protect the body from coronavirus infection may wane over time, meriting a third shot.
In the first study, researchers in Qatar (a highly inoculated country with more than 82% of people fully vaccinated) investigated more than 900,000 PCR tests of people vaccinated with Pfizer (the most popular shot there), and found that their protection against any infection started to decrease markedly about four months after their second jab.
The researchers found that Pfizer's protection against infection was "negligible" just after a first dose, rising to 36.8% three weeks later. When people then received their second shot, their vaccine protection jumped to 77.5% within about four weeks, and protection against "any severe, critical, or fatal case of COVID-19 increased rapidly," the researchers said, reaching 96% or higher in the first two months that people were fully vaccinated.
That strong protection against the worst things COVID-19 can do to a person persisted for at least half a year.
"No evidence was found for an appreciable waning of protection against hospitalization and death, which remained robust - generally at 90% or higher - for 6 months after the second dose," the researchers said.
Meanwhile, Pfizer's protection against milder and more negligible COVID-19 infections declined.
After people had been fully vaccinated for about five to seven months, the researchers observed Pfizer's vaccine effectiveness hovering around 20%, though only about a third of those infections were diagnosed "on the basis of symptoms," suggesting that many of them were silent, asymptomatic infections.
"Protection against asymptomatic infection diminished more quickly than that against symptomatic infection, as would be expected in a vaccine that prevents symptoms," the researchers said. "These findings suggest that a large proportion of the vaccinated population could lose its protection against infection in the coming months."
Other research from Qatar suggests that breakthough infections are less infectious than those in unvaccinated individuals, making them less likely to spread.
The second NEJM study, conducted in Israel, looked at 4,868 healthcare workers who'd been fully vaccinated with Pfizer's vaccine. It reported that their neutralizing antibodies to COVID-19 are "substantially" lowered by six months after receiving their second dose of Pfizer's vaccine - a trend that's especially true for men, people over age 65, and people with weakened immune systems.
Even so, only 20 of those healthcare workers had breakthrough infections during the study period, suggesting, again, that vaccine protection remains robust for many months after people get jabbed.
It's normal for neutralizing antibodies to decline after vaccination, and neutralizing antibodies are not the only element of immune response that protects us from reinfection, but vaccines for other conditions such as mumps, measles, and rubella only show small decreases of about 5% to 10% each year in neutralizing antibody levels, the researchers said.
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TOKYO (Reuters) -Japan has struck a deal with Pfizer Inc to be supplied with another 120 million COVID-19 vaccine doses from January 2022, its health ministry said on Friday. Japan kicked off its inoculation effort in February using imported doses of the shot developed by Pfizer and BioNTech SE. After a late start, about 63% of Japan's population is now fully vaccinated, exceeding the level in the United States.
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The Delta variant of the coronavirus does not appear to cause more severe disease in children than earlier forms of the virus, a UK study suggests. Earlier this year, the research team found the Alpha variant of the virus did not appear to make children sicker than the so-called wild, or original, form of the virus, first seen in China. New data suggests that kids also do not get any sicker from Delta than they did from Alpha.
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HELSINKI (Reuters) -Finland on Thursday paused the use of Moderna's COVID-19 vaccine for younger males due to reports of a rare cardiovascular side effect, joining Sweden and Denmark in limiting its use. Mika Salminen, director of the Finnish health institute, said Finland would instead give Pfizer's vaccine to men born in 1991 and later. Finland offers shots to people aged 12 and over.
Now she is "suspicious" of some of his other choices.
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Data: KFF September 2021 Vaccine Monitor; Chart: Jacque Schrag/AxiosConservative media sometimes blame the problem of the unvaccinated on people of color, but the data show vaccine resistance is mostly about red America and younger adults now.Why it matters: The numbers show a much different story about where we still need to be focusing our vaccination efforts.Stay on top of the latest market trends and economic insights with Axios Markets. Subscribe for freeBy the numbers: 59% of the unvaccina
Rosie Mattio said cannabis gummies, drinks, and topicals helped her manage training, taking care of her 4 kids, and running her marketing agency.
BENGALURU (Reuters) -Two Indian drugmakers have requested permission to end late-stage trials of their generic versions of Merck & Co's oral antiviral drug molnupiravir for moderate COVID-19, raising questions about how effective the experimental medicine is for that group of patients. The Indian drug regulator's internal expert committee disclosed on its website that Aurobindo Pharma Ltd and MSN Laboratories had presented interim clinical trial data for this group of patients and asked to end the trials. Merck and partner Ridgeback Biotherapeutics last week said molnupiravir had nearly halved the risk of hospitalization https://www.reuters.com/business/healthcare-pharmaceuticals/mercks-covid-19-pill-cuts-risk-death-hospitalization-by-50-study-2021-10-01 or death in patients at risk of severe disease who had mild-to-moderate COVID-19, results hailed by experts as potentially a major advance in fight against the illness.
Researchers say the drug could integrate itself into patients' DNA, theoretically leading to cancer. Merck says its tests show that isn't an issue.
If COVID-19 vaccines are effective and widely employed, what risk could an unmasked 2-year-old pose? [Opinion]
Read full article at Honolulu Star-Advertiser
09 October, 2021 - 08:20am
"With new cases in children in the US continuing to be at a high level, this submission is an important step in our ongoing effort against COVID-19," Pfizer wrote on Twitter.
The FDA has tentatively scheduled a meeting on October 26 to review Pfizer's request.
While adults and teenagers have been benefitting from vaccine protection for months, young kids have had few options beyond masks and social distancing in the face of the Delta variant and while returning to school in person.
"Delta has made COVID a pediatric problem," said Dr. Andrew Pavia, pediatric infectious disease specialist at the University of Utah.
But if all goes well and the government green-lights Pfizer's shot, here's what parents will need to know.
Pavia has served on advisory groups that review and suggest improvements to the US vaccine safety system — "I've been under the hood," he said.
The COVID-19 vaccine, he added, "isn't brand new — this isn't understudied."
So far, Pfizer's vaccine has been administered to more than 230 million Americans and has proven safe in teenagers, Pavia explained. Another factor that should reassure parents is that the US has a robust reporting system for detecting vaccine safety issues and side effects.
"It's been able to detect very rare side effects very effectively," Pavia said. He gave the example of myocarditis, inflammation of the heart muscle.
"Myocarditis in women occurs with a frequency of about two to five per million, and our safety systems are good enough to pick something up that's that rare," Pavia said.
Dr. Simon Li, too, has peered behind the curtain. He's a principal investigator helping run the vaccine study on kids in New Jersey alongside Pfizer, and an associate professor of pediatrics at Rutgers.
"The studies that are being done have been extremely, extremely cautious and careful and very well run," Li said.
Li's own kids are 4, 8, and 10, so not old enough to get the shots yet. The only reason he hasn't enrolled then in a vaccine study, he said, is that his role with Pfizer prohibits him from doing so.
"When it comes out, I'll be first in line" Li said of vaccinating his children.
Not exactly. The kids' vaccine is a two-shot formula, but it comes in smaller doses. Pfizer gave 30-milligram doses to adults, but 5- to 11-year-olds are receiving less than half of that.
Li likened the process to the comparatively small doses of other medicines, like Tylenol, that we give children. Children don't need the same dosage because they are smaller than adults and because their bodies process drugs differently.
"It's size and their ability to break down and react," Li said.
Some doctors say that taking pain medication to dim potential vaccine side effects isn't a big deal. But other experts and the CDC recommend against taking it, since "it is not known how these medications might affect how well the vaccine works." (A caveat: If your child takes regular medication for another reason, they should maintain their normal routine.)
Side effects are a sign that your body is learning how to respond to the virus and building immunity. While there's not research pain medicine would interrupt that process, the CDC is erring on the side of caution.
Once his kids can get the shots, Li said, "I will not be giving them anything — I want them to have that full immune reaction to build immunity against the virus."
There is not yet data on how well Moderna's vaccine works among children, but real-world study published in the New England Journal of Medicine last month found that among adults, Pfizer's vaccine had an efficacy rate of 88.8%, compared to Moderna's 96.3%.
Li says the difference is tiny compared to the risk of leaving your child unvaccinated for weeks or months while Moderna seeks FDA authorization. So it's best not to wait.
"I would advise them to get vaccinated as soon as they can. Those differences are so small. That's just silly," he said.
Nearly 5.9 million children have tested positive for the virus since the start of the pandemic, according to the American Academy of Pediatrics. COVID-19 deaths among children are uncommon — the CDC has recorded 650 so far. But there have been 5,217 cases of multisystem inflammatory syndrome in children, a rare but serious condition associated with COVID-19 in which body parts like the heart, lungs, brain, or other organs become inflamed.
Call your pediatrician if your child has any issue — "they'll be ready," Li said.
Most pediatricians are by now well-versed in the vaccine and its side effects. They are also required to report any clinically significant side effects to the Vaccine Adverse Event Reporting System, an early warning system run by the CDC and FDA.
09 October, 2021 - 08:20am