Pfizer to apply for US vaccine approval for younger children in November

Health

Financial Times 14 September, 2021 - 07:30pm 12 views

Booster shots can wait, NYC immunology professor says

PIX11 News 15 September, 2021 - 07:50am

Moderna may have the effectiveness edge over Pfizer

Yahoo News 15 September, 2021 - 04:00am

Why it matters: The effectiveness gap could always disappear with more data, and both vaccines remain very effective against severe disease. But if the gap does hold up, it raises questions about whether the two vaccines should be treated the same way policy-wise.

Driving the news: Several studies — both preprints and those that have been peer-reviewed — have found a difference between the two vaccines' effectiveness over time, although some experts have cautioned that this could stem from flawed head-to-head comparisons.

The studies have evaluated different measures of effectiveness, but all have found that effectiveness against severe disease remains relatively high.

"There have been sort of signals from enough separate sources that start to paint a picture that may reflect a real biological phenomenon — a real difference. I’m starting to believe that there’s something underlying it," said Natalie Dean, an Emery professor who specializes in vaccine study design.

Zoom in: In a study released last week, the CDC found that Moderna was significantly more effective against hospitalizations and emergency department or urgent care encounters than the Pfizer or J&J vaccines.

A second smaller study found more similar effectiveness level against hospitalization between the two mRNA vaccines.

Between the lines: Pfizer was the first vaccine authorized for use in the U.S. and began being administered several weeks before the Moderna vaccine.

"Because of the way the rollouts happened, the oldest and most vulnerable and sickest people, like nursing home residents, got Pfizer," said Cornell virologist John Moore.

That means it's possible that some of the effectiveness gap showing up in some studies is a result of Pfizer being administered earlier and in more vulnerable populations.

However, the large CDC study that found a significant difference in the vaccines' effectiveness found that Moderna's was higher across all ages.

Possible reasons for the difference include that Moderna has a much higher dosing regimen than Pfizer, and the second shot is given after a slightly longer interval.

And, while the vaccines are both made using mRNA technology, they have structural differences.

Yes, but: Both vaccines are nearly equal in their capacity to "do what a vaccine needs to do, which is protect against severe illness," said Paul Offit, director of the Vaccine Education Center at the Children's Hospital of Philadelphia.

The bottom line: The Moderna data may more closely resemble Pfizer's after more time passes. But it may be unwise to use one as a proxy for the other.

"It's not clear that any lesson we see from Pfizer will directly translate to Moderna," Dean said. "I think if you asked this question a few months ago, when there really [weren't] any signals of a difference, people would very much lump them together in their mind."

What we're watching: There's a lot more data — particularly from other countries, like Israel — on Pfizer's waning effectiveness, and the effect of booster shots on restoring effectiveness to original levels.

But if that data isn't applicable to Moderna, regulators may not yet have much data to work with when making booster decisions — a process that is already highly controversial.

"We won't know the real Moderna-specific data for some time now, about restoring effectiveness and how durable that is," said Eric Topol, executive vice president of Scripps Research.

Topol said there have been signs Moderna's effectiveness wanes over time to some degree. "It just may be longer and it may be less," Topol added.

The fistfight between two factions inside the Taliban leadership took place inside the Afghan presidential palace in Kabul, the BBC reported.

The editorial slammed the Florida Republican for "crass opportunism and disregard for the greater good."

A woman had an affair with a married man and gave birth to a girl, who was then adopted by the man and his wife.

SAN FRANCISCO - A creative director filed suit against online bookmarking site Pinterest and two of its co-founders Monday, alleging that she helped create the idea for the site but never received any recognition or payment. Christine Martinez, a creative director and storyteller, alleges that she co-created Pinterest and made it clear she expected to receive money if her ideas were successful. But after the company went public in 2019, raising about $1.4 billion, she received nothing, she says.

As companies continue to ramp up vaccine mandates to combat the contagious delta variant, some institutions are giving employees a chance to opt-out of getting the vaccine if they have a medical exemption. Dr. David Dowdy, an epidemiologist at the Johns Hopkins Bloomberg School of Public Health, told ABC News that the large and growing data on the three coronavirus vaccines shows there are no immediate health issues or side effects for most people with pre-existing medical conditions. The current guidance from the U.S. Centers for Disease Control and Prevention, said the two-dose mRNA vaccines and the one dose Johnson & Johnson vaccine are safe for almost all patients.

Fears about the coronavirus vaccine ran through the family. Those fears are leading people to choose not to be inoculated, county officials say.

"They didn't like seeing a fat person dressed the way I am."View Entire Post ›

YouTube/KARE 11The FBI has been called in to assist local authorities in rural Wisconsin after four young friends from Minnesota were found murdered and “randomly” left in an abandoned SUV in a cornfield.Authorities in Dunn County, Wisconsin, where the quadruple homicide victims were discovered Sunday, have made no secret that they have been left baffled by the crime.“It’s highly unusual for this area. Obviously we’ve had homicides in the last several years, but something of this magnitude—[I’m]

If you’re on Social Security there is good news, and some not quite so good news, in the latest official inflation report out from Uncle Sam on Tuesday. The good news is that you’re on track for the biggest annual cost of living adjustment next year in over a decade. Based on the U.S. Labor Department’s consumer price data for August, Social Security is on track to hike benefits 5.9% for 2022 when it makes the official announcement next month.

Trump reportedly told Pence he wouldn't want to be his friend anymore if he didn't block election certification

New York has passed a new law that bans the sale of gas vehicles starting in 2035.

Shannen Doherty will appear in the upcoming Lifetime movie List of a Lifetime, which centers around a woman who has been diagnosed with breast cancer

Healthy children aged 12 to 15 will be invited to come forward for a jab from next week.

"I've never experienced that level of hatred and the threat of physical violence," Union recalls to PEOPLE

Avril Lavigne wowed fans with her "eternal youth" at the 2021 MTV Video Music Awards (VMAs) in New York City.

By the time Rep. Jim Jordan, R-Ohio, posted a tweet on Sept. 7 declaring that “Real America is done with #COVID19,” the pandemic, and how one responded to it, had already metastasized into a political litmus test.

SEOUL (Reuters) -Both North Korea and South Korea test fired ballistic missiles on Wednesday, the latest volley in an arms race https://www.reuters.com/article/us-northkorea-missiles-southkorea-analys-idUSKBN2BM0G8 that has seen both countries develop increasingly sophisticated weapons while efforts to get talks going on defusing tension prove fruitless. South Korea tested a submarine-launched ballistic missile https://www.reuters.com/world/asia-pacific/skorea-blazes-new-path-with-most-potent-conventional-missile-submarine-2021-09-08(SLBM), becoming the first country without nuclear weapons to develop such a system. South Korea President Moon was attending that test firing when word came of the North Korean launches, its first ballistic missile tests since March https://tmsnrt.rs/2PFT4eW.

Moderna may have the effectiveness edge over Pfizer

CNN 15 September, 2021 - 04:00am

Why it matters: The effectiveness gap could always disappear with more data, and both vaccines remain very effective against severe disease. But if the gap does hold up, it raises questions about whether the two vaccines should be treated the same way policy-wise.

Driving the news: Several studies — both preprints and those that have been peer-reviewed — have found a difference between the two vaccines' effectiveness over time, although some experts have cautioned that this could stem from flawed head-to-head comparisons.

The studies have evaluated different measures of effectiveness, but all have found that effectiveness against severe disease remains relatively high.

"There have been sort of signals from enough separate sources that start to paint a picture that may reflect a real biological phenomenon — a real difference. I’m starting to believe that there’s something underlying it," said Natalie Dean, an Emery professor who specializes in vaccine study design.

Zoom in: In a study released last week, the CDC found that Moderna was significantly more effective against hospitalizations and emergency department or urgent care encounters than the Pfizer or J&J vaccines.

A second smaller study found more similar effectiveness level against hospitalization between the two mRNA vaccines.

Between the lines: Pfizer was the first vaccine authorized for use in the U.S. and began being administered several weeks before the Moderna vaccine.

"Because of the way the rollouts happened, the oldest and most vulnerable and sickest people, like nursing home residents, got Pfizer," said Cornell virologist John Moore.

That means it's possible that some of the effectiveness gap showing up in some studies is a result of Pfizer being administered earlier and in more vulnerable populations.

However, the large CDC study that found a significant difference in the vaccines' effectiveness found that Moderna's was higher across all ages.

Possible reasons for the difference include that Moderna has a much higher dosing regimen than Pfizer, and the second shot is given after a slightly longer interval.

And, while the vaccines are both made using mRNA technology, they have structural differences.

Yes, but: Both vaccines are nearly equal in their capacity to "do what a vaccine needs to do, which is protect against severe illness," said Paul Offit, director of the Vaccine Education Center at the Children's Hospital of Philadelphia.

The bottom line: The Moderna data may more closely resemble Pfizer's after more time passes. But it may be unwise to use one as a proxy for the other.

"It's not clear that any lesson we see from Pfizer will directly translate to Moderna," Dean said. "I think if you asked this question a few months ago, when there really [weren't] any signals of a difference, people would very much lump them together in their mind."

What we're watching: There's a lot more data — particularly from other countries, like Israel — on Pfizer's waning effectiveness, and the effect of booster shots on restoring effectiveness to original levels.

But if that data isn't applicable to Moderna, regulators may not yet have much data to work with when making booster decisions — a process that is already highly controversial.

"We won't know the real Moderna-specific data for some time now, about restoring effectiveness and how durable that is," said Eric Topol, executive vice president of Scripps Research.

Topol said there have been signs Moderna's effectiveness wanes over time to some degree. "It just may be longer and it may be less," Topol added.

The fistfight between two factions inside the Taliban leadership took place inside the Afghan presidential palace in Kabul, the BBC reported.

The editorial slammed the Florida Republican for "crass opportunism and disregard for the greater good."

As companies continue to ramp up vaccine mandates to combat the contagious delta variant, some institutions are giving employees a chance to opt-out of getting the vaccine if they have a medical exemption. Dr. David Dowdy, an epidemiologist at the Johns Hopkins Bloomberg School of Public Health, told ABC News that the large and growing data on the three coronavirus vaccines shows there are no immediate health issues or side effects for most people with pre-existing medical conditions. The current guidance from the U.S. Centers for Disease Control and Prevention, said the two-dose mRNA vaccines and the one dose Johnson & Johnson vaccine are safe for almost all patients.

SAN FRANCISCO - A creative director filed suit against online bookmarking site Pinterest and two of its co-founders Monday, alleging that she helped create the idea for the site but never received any recognition or payment. Christine Martinez, a creative director and storyteller, alleges that she co-created Pinterest and made it clear she expected to receive money if her ideas were successful. But after the company went public in 2019, raising about $1.4 billion, she received nothing, she says.

YouTube/KARE 11The FBI has been called in to assist local authorities in rural Wisconsin after four young friends from Minnesota were found murdered and “randomly” left in an abandoned SUV in a cornfield.Authorities in Dunn County, Wisconsin, where the quadruple homicide victims were discovered Sunday, have made no secret that they have been left baffled by the crime.“It’s highly unusual for this area. Obviously we’ve had homicides in the last several years, but something of this magnitude—[I’m]

A one-year expansion of the U.S. child tax credit, a policy championed by President Joe Biden and his fellow Democrats over Republican opposition, has disproportionately benefited states that voted for former President Donald Trump in 2020, a Reuters review of Treasury Department data has found. Congressional Democrats are now seeking to extend the expansion for four additional years as part of $3.5 trillion social spending legislation opposed by Trump's fellow Republicans. The one-year expansion - part of COVID-19 pandemic relief legislation https://www.reuters.com/article/us-health-coronavirus-usa-congress/bidens-1-9-trillion-covid-19-bill-wins-final-approval-in-house-idUSKBN2B215E signed by Biden in March, is expected to funnel $105 billion to American families, many still hurting from the economic effects of the public health crisis.

If you’re on Social Security there is good news, and some not quite so good news, in the latest official inflation report out from Uncle Sam on Tuesday. The good news is that you’re on track for the biggest annual cost of living adjustment next year in over a decade. Based on the U.S. Labor Department’s consumer price data for August, Social Security is on track to hike benefits 5.9% for 2022 when it makes the official announcement next month.

Fears about the coronavirus vaccine ran through the family. Those fears are leading people to choose not to be inoculated, county officials say.

Trump reportedly told Pence he wouldn't want to be his friend anymore if he didn't block election certification

New York has passed a new law that bans the sale of gas vehicles starting in 2035.

Healthy children aged 12 to 15 will be invited to come forward for a jab from next week.

Shannen Doherty will appear in the upcoming Lifetime movie List of a Lifetime, which centers around a woman who has been diagnosed with breast cancer

via FacebookIn a stunning turn of events, a South Carolina man was charged Tuesday with shooting troubled attorney Alex Murdaugh in the head in an assisted-suicide plot to secure $10 million in insurance money—just three months after Murdaugh’s wife and son were murdered.The alleged conspiracy was laid out in court documents released after Curtis Edward Smith, 61, was collared for the botched Sept. 4 shooting, which Murdaugh, 53, survived.“Mr. Murdaugh supplied Mr. Smith with a firearm and direc

Pfizer stock inched higher Tuesday on expectations for the firm could release results for its Covid vaccine in young children next month.

Are avocados the answer to belly fat? That’s the question making a comeback after a new study on 105 obese and overweight adults found that women who consumed the smashable on-toast fave as part of their daily meals did, in fact, see a reduction in visceral fat around the abdominal region.

Veronica Wolski, the QAnon adherent whose recent hospitalization made her a cause celebre for the controversial medication ivermectin, died in the intensive care unit of Amita Health Resurrection Medical Center early Monday, a hospital spokeswoman said. She was 64. Wolski’s cause of death was pneumonia due to COVID-19 infection with hypothyroidism as a contributing factor, a spokeswoman for ...

Hint: It's one of our faves!

Moderna may have the effectiveness edge over Pfizer

The Straits Times 15 September, 2021 - 04:00am

Why it matters: The effectiveness gap could always disappear with more data, and both vaccines remain very effective against severe disease. But if the gap does hold up, it raises questions about whether the two vaccines should be treated the same way policy-wise.

Driving the news: Several studies — both preprints and those that have been peer-reviewed — have found a difference between the two vaccines' effectiveness over time, although some experts have cautioned that this could stem from flawed head-to-head comparisons.

The studies have evaluated different measures of effectiveness, but all have found that effectiveness against severe disease remains relatively high.

"There have been sort of signals from enough separate sources that start to paint a picture that may reflect a real biological phenomenon — a real difference. I’m starting to believe that there’s something underlying it," said Natalie Dean, an Emery professor who specializes in vaccine study design.

Zoom in: In a study released last week, the CDC found that Moderna was significantly more effective against hospitalizations and emergency department or urgent care encounters than the Pfizer or J&J vaccines.

A second smaller study found more similar effectiveness level against hospitalization between the two mRNA vaccines.

Between the lines: Pfizer was the first vaccine authorized for use in the U.S. and began being administered several weeks before the Moderna vaccine.

"Because of the way the rollouts happened, the oldest and most vulnerable and sickest people, like nursing home residents, got Pfizer," said Cornell virologist John Moore.

That means it's possible that some of the effectiveness gap showing up in some studies is a result of Pfizer being administered earlier and in more vulnerable populations.

However, the large CDC study that found a significant difference in the vaccines' effectiveness found that Moderna's was higher across all ages.

Possible reasons for the difference include that Moderna has a much higher dosing regimen than Pfizer, and the second shot is given after a slightly longer interval.

And, while the vaccines are both made using mRNA technology, they have structural differences.

Yes, but: Both vaccines are nearly equal in their capacity to "do what a vaccine needs to do, which is protect against severe illness," said Paul Offit, director of the Vaccine Education Center at the Children's Hospital of Philadelphia.

The bottom line: The Moderna data may more closely resemble Pfizer's after more time passes. But it may be unwise to use one as a proxy for the other.

"It's not clear that any lesson we see from Pfizer will directly translate to Moderna," Dean said. "I think if you asked this question a few months ago, when there really [weren't] any signals of a difference, people would very much lump them together in their mind."

What we're watching: There's a lot more data — particularly from other countries, like Israel — on Pfizer's waning effectiveness, and the effect of booster shots on restoring effectiveness to original levels.

But if that data isn't applicable to Moderna, regulators may not yet have much data to work with when making booster decisions — a process that is already highly controversial.

"We won't know the real Moderna-specific data for some time now, about restoring effectiveness and how durable that is," said Eric Topol, executive vice president of Scripps Research.

Topol said there have been signs Moderna's effectiveness wanes over time to some degree. "It just may be longer and it may be less," Topol added.

The fistfight between two factions inside the Taliban leadership took place inside the Afghan presidential palace in Kabul, the BBC reported.

The editorial slammed the Florida Republican for "crass opportunism and disregard for the greater good."

As companies continue to ramp up vaccine mandates to combat the contagious delta variant, some institutions are giving employees a chance to opt-out of getting the vaccine if they have a medical exemption. Dr. David Dowdy, an epidemiologist at the Johns Hopkins Bloomberg School of Public Health, told ABC News that the large and growing data on the three coronavirus vaccines shows there are no immediate health issues or side effects for most people with pre-existing medical conditions. The current guidance from the U.S. Centers for Disease Control and Prevention, said the two-dose mRNA vaccines and the one dose Johnson & Johnson vaccine are safe for almost all patients.

SAN FRANCISCO - A creative director filed suit against online bookmarking site Pinterest and two of its co-founders Monday, alleging that she helped create the idea for the site but never received any recognition or payment. Christine Martinez, a creative director and storyteller, alleges that she co-created Pinterest and made it clear she expected to receive money if her ideas were successful. But after the company went public in 2019, raising about $1.4 billion, she received nothing, she says.

YouTube/KARE 11The FBI has been called in to assist local authorities in rural Wisconsin after four young friends from Minnesota were found murdered and “randomly” left in an abandoned SUV in a cornfield.Authorities in Dunn County, Wisconsin, where the quadruple homicide victims were discovered Sunday, have made no secret that they have been left baffled by the crime.“It’s highly unusual for this area. Obviously we’ve had homicides in the last several years, but something of this magnitude—[I’m]

If you’re on Social Security there is good news, and some not quite so good news, in the latest official inflation report out from Uncle Sam on Tuesday. The good news is that you’re on track for the biggest annual cost of living adjustment next year in over a decade. Based on the U.S. Labor Department’s consumer price data for August, Social Security is on track to hike benefits 5.9% for 2022 when it makes the official announcement next month.

A one-year expansion of the U.S. child tax credit, a policy championed by President Joe Biden and his fellow Democrats over Republican opposition, has disproportionately benefited states that voted for former President Donald Trump in 2020, a Reuters review of Treasury Department data has found. Congressional Democrats are now seeking to extend the expansion for four additional years as part of $3.5 trillion social spending legislation opposed by Trump's fellow Republicans. The one-year expansion - part of COVID-19 pandemic relief legislation https://www.reuters.com/article/us-health-coronavirus-usa-congress/bidens-1-9-trillion-covid-19-bill-wins-final-approval-in-house-idUSKBN2B215E signed by Biden in March, is expected to funnel $105 billion to American families, many still hurting from the economic effects of the public health crisis.

Fears about the coronavirus vaccine ran through the family. Those fears are leading people to choose not to be inoculated, county officials say.

Trump reportedly told Pence he wouldn't want to be his friend anymore if he didn't block election certification

New York has passed a new law that bans the sale of gas vehicles starting in 2035.

Healthy children aged 12 to 15 will be invited to come forward for a jab from next week.

Shannen Doherty will appear in the upcoming Lifetime movie List of a Lifetime, which centers around a woman who has been diagnosed with breast cancer

via FacebookIn a stunning turn of events, a South Carolina man was charged Tuesday with shooting troubled attorney Alex Murdaugh in the head in an assisted-suicide plot to secure $10 million in insurance money—just three months after Murdaugh’s wife and son were murdered.The alleged conspiracy was laid out in court documents released after Curtis Edward Smith, 61, was collared for the botched Sept. 4 shooting, which Murdaugh, 53, survived.“Mr. Murdaugh supplied Mr. Smith with a firearm and direc

Pfizer stock inched higher Tuesday on expectations for the firm could release results for its Covid vaccine in young children next month.

Are avocados the answer to belly fat? That’s the question making a comeback after a new study on 105 obese and overweight adults found that women who consumed the smashable on-toast fave as part of their daily meals did, in fact, see a reduction in visceral fat around the abdominal region.

Veronica Wolski, the QAnon adherent whose recent hospitalization made her a cause celebre for the controversial medication ivermectin, died in the intensive care unit of Amita Health Resurrection Medical Center early Monday, a hospital spokeswoman said. She was 64. Wolski’s cause of death was pneumonia due to COVID-19 infection with hypothyroidism as a contributing factor, a spokeswoman for ...

Hint: It's one of our faves!

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