When Will the Covid-19 Vaccine Be Available for Children? The Race Is On.

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Barron's 03 August, 2021 - 01:45pm 42 views

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Researchers in Singapore have conducted a study showing that the messenger RNA- (mRNA) based coronavirus disease 2019 (COVID-19) vaccines developed by Pfizer-BioNTech and Moderna are highly effective at protecting against symptomatic and severe disease following infection with the rapidly spreading B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

The team conducted a multi-center retrospective cohort study of vaccinated and unvaccinated individuals who had been admitted to hospital following infection with the B.1.617.2 variant of concern.

“To our knowledge, we provide the first data characterizing the impact of vaccination on virologic kinetics by the B.1.617.2 variant,” writes Barnaby Young from the National Centre for Infectious Diseases in Singapore and colleagues.

The team found that individuals fully vaccinated with either Pfizer-BioNTech’s BNT162b2 vaccine or Moderna’s mRNA-1273 product were significantly less likely to develop moderate or severe outcomes following B.1.617.2 infection than unvaccinated individuals.

Vaccination was associated with fewer symptoms, lower peak biomarkers of systemic inflammation, and better clinical outcomes. It was also associated with a more rapid decline in viral RNA load and a robust serologic response.

“Vaccination remains a key strategy for control of COVID-19 pandemic,” says Young and colleagues.

A pre-print version of the research paper isa available on the medRxiv* server, while the article undergoes peer review.

Phase 3 clinical trials of mRNA-based vaccines have demonstrated efficacies of 92% to 95% in preventing symptomatic and severe disease following SARS-CoV-2 infection.

While the mass rollout of these vaccines has reduced infection and mortality rates in many countries, the emergence of SARS-CoV-2 variants containing mutations in the viral spike protein has led to growing concerns regarding increased transmissibility and resistance to vaccine-induced immunity.

The spike protein is the main structure the virus uses to infect cells and a primary target of binding and neutralizing antibodies following natural infection or vaccination.

While variants of concern such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.2 (delta) have all been shown to exhibit increased transmissibility, the B.1.1.7 and B.1.617.2 strains have also been associated with increased disease severity and hospitalization.

Following the emergence of B.1.617.2 in India, this variant rapidly spread to other countries and had become the most frequently sequenced lineage worldwide by the end of June 2021.

Young and colleagues conducted a multi-center retrospective cohort study to characterize the clinical, virologic and serologic features of vaccinated adults with breakthrough B.1.617.2 infection. The results were compared with those of unvaccinated patients who also had B.1.617.2 infection.

Of 218 individuals diagnosed with B.1.617.2 infection by polymerase chain reaction (PCR) testing, 88 had received a vaccine.

Seventy-one individuals were fully vaccinated and therefore met the definition for vaccine-breakthrough infection. Sixty-six of these participants (93%) had received two doses of the Pfizer-BioNTech BNT162b2 vaccine.

The vaccine-breakthrough infection cohort was significantly older than the unvaccinated cohort, at a median of 56 years (age range 39 to 64) versus 39.5 years (age range 30 to 58). Individuals with breakthrough infection were also significantly more likely to be asymptomatic (at 28.2% versus 9.2%) and to have fewer symptoms if they were symptomatic.

Unvaccinated individuals had higher levels of biomarkers known to be associated with more severe disease, including lymphocyte count, C-reactive protein, lactate dehydrogenase and alanine transferase.

Multivariate logistic regression analysis revealed that vaccinated individuals were 97% less likely to develop severe COVID-19 that required oxygen supplementation or moderate disease (defined as development of pneumonia).

“The finding of diminished severity with B.1.617.2 infection in vaccinated individuals is reassuring and corroborates emerging data from the United Kingdom which have found that mRNA vaccination remains protective against symptomatic and severe disease,” says the team.

The initial PCR cycle threshold (Ct) values (number of cycles required for virus detection) were similar between the vaccinated and unvaccinated groups, at 19.2 versus 18.8.

However, the median Ct value increased more rapidly over time among vaccinated individuals, pointing to a faster decline in viral load.

The researchers say this has implications in terms of transmissibility and infection control policy.

“A shorter duration of infectivity may allow a shorter duration of isolation for vaccinated individuals,” they write.

Of 66 vaccinated individuals with available serologic data, all (100%) had detectable anti-spike antibodies during the first week of illness, compared with seven (16%) of 45 unvaccinated individuals.

“The mRNA vaccines are highly effective at preventing symptomatic and severe COVID-19 associated with B.1.617.2 infection,” says Young and colleagues. “Vaccination is associated with faster decline in viral RNA load and a robust serological response.”

The researchers say that while vaccine-breakthrough infections will continue to be observed, it is likely that there will be a shift towards a milder disease spectrum with more widespread implementation of vaccination programs.

“Rapid and widespread implementation of vaccination programs remains a key strategy for control of the COVID-19 pandemic,” they conclude.

medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

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Posted in: Men's Health News | Medical Research News | Women's Health News | Disease/Infection News

Tags: Alanine, Antibodies, Coronavirus, Coronavirus Disease COVID-19, C-Reactive Protein, CT, Efficacy, Healthcare, Hospital, immunity, Infection Control, Infectious Diseases, Inflammation, Lymphocyte, Mortality, Oxygen, Pandemic, Pneumonia, Polymerase, Polymerase Chain Reaction, Protein, Research, Respiratory, RNA, SARS, SARS-CoV-2, Severe Acute Respiratory, Severe Acute Respiratory Syndrome, Spike Protein, Syndrome, Vaccine, Virus

Sally first developed an interest in medical communications when she took on the role of Journal Development Editor for BioMed Central (BMC), after having graduated with a degree in biomedical science from Greenwich University.

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Robertson, Sally. (2021, August 02). Study shows efficacy of Pfizer-BioNTech and Moderna vaccines against SARS-CoV-2 delta variant. News-Medical. Retrieved on August 03, 2021 from https://www.news-medical.net/news/20210802/Study-shows-efficacy-of-Pfizer-BioNTech-and-Moderna-vaccines-against-SARS-CoV-2-delta-variant.aspx.

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One MASSIVE mistake means Meghan & Harry have 'no more currency remaining'

ABC Action News 03 August, 2021 - 06:30pm

We pay for your stories and videos

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Since leaving the UK last year, the Duke and Duchess of Sussex have been in the media spotlight, securing lucrative deals with the likes of Apple TV, Netflix and Spotify - the first of which was their bombshell Oprah interview.

Harry also recently announced a £29m publishing deal to release a series of memoirs - further converting the couple's "currency" as members of the royal family into million-pound mega-deals.

But Vanity Fair's royal editor Katie Nicholl has now questioned what the Sussexes' would have left to trade after these ventures come to an end.

She told the True Royalty TV: "I think the biggest threat to Harry and Meghan, once these book deals are done and the podcasts are done and Spotify, then what is their currency?"

There are fears that the growing divide between Harry and his brother may never be fixed as William finds it “impossible to trust him again”, pals fear.

But with Meghan blowing out 40 ­candles on her birthday cake on Wednesday, it’s expected that the very public fall-out will briefly be put to one side.

ROYALS ‘TO SHARE MEGHAN MARKLE 40TH BIRTHDAY MESSAGE “THROUGH GRITTED TEETH”’

An expert has claimed today that the Royals are expected to share a birthday message to Meghan Markle to mark her 40th “through gritted teeth”. It has been said they don’t want to make the rift worse.

Despite Meghan and Harry quitting the Firm more than a year ago and starting a new life in the US before unleashing a string of allegations against the Royals, Meghan will still receive a birthday message.

Royal commentator Phil Dampier told the Sun Online: “But whether a present will be sent privately, I don’t know, such is the state of the relationship.

MEGHAN MARKLE ‘BORED OUT OF HER MIND BY ROYALS BALMORAL TRIP, SAYS EXPERT

Phil Dampier claimed that the Duchess of Sussex is focused on a “full-on Hollywood” life as she reaches her milestone 40th birthday tomorrow.

Phil told Fabulous: “Harry and Meghan certainly won’t miss going to Balmoral as a guest of the Queen.

“They would have been bored out of their minds and found it stifling.”

It has been reported that Meghan is hiring Oprah Winfrey’s party planner for her 40th birthday bash which will host 65 and not break Covid rules.

The Duchess of Sussex has reportedly tasked Colin Cowie with planning the milestone birthday at her and Harry’s £11million mansion in Santa Barbara, California.

THE ONE WORD KATE MIDDLETON’S NANNY IS BANNED FROM SAYING

Maria Borrallo trained at the prestigious Norland College in Bath, and as part of her training she was instructed not to say one word in particular.

Norland expert Louise Heren, and author of Nanny in a Book, discovered that there is one word Maria must not say on the job.

Speaking to the Mirror, Louise explained that that Norland nannies are banned from saying ‘kids’ and must instead use the children’s names at all times.

Louise says: “The word kid is banned. It's a mark of respect for the children as individuals.”

BLOOM HITS BACK AT COMPLAINTS ABOUT HBO’S THE PRINCE MOCKING ROYAL FAMILY

ORLANDO Bloom has hit back at scathing criticism of his new TV series The Prince, which has been branded “shameful” for its portrayal of the Royal Family.

The satire hit HBO Max last month, with the Pirates Of The Caribbean actor, 44, playing the role of Prince Harry.

The show’s 12 episodes are in cartoon form but already attracted hugely negative publicity for their portrayal of the late Prince Philip, and his failing health before his death.

In an interview with the Hollywood Reporter, the Brit said: “I hadn’t met [Prince Harry] when I signed up to do it, and I subsequently met him and he’s such a nice guy.

“This guy is so nice, and I think he’s got a great sense of humour.

“I hope he maintains that through this because they’re sort of on a pedestal.

“We’re showing real adoration to them in one form or another. I try to justify it, because quite frankly, if I’m honest, it’s not like me to poke fun at anyone but it is done with affection.

“When I was in my mid-20s, there was so many different people poking fun at me and, in a way, it’s a sign of appreciation.”

FIRST LOOK AT IMELDA STAUNTON AS THE QUEEN ON SET OF THE CROWN SEASON 5

FERGIE SAYS SHE AND DIANA WOULD HAVE BEEN ‘PARTY GRANNIES’ AND ‘FIRST ON THE BOUNCY CASTLE’

Sarah Ferguson gushed in an interview with Bella magazine after recalling her friendship with Princess Diana. She said if Princess Diana was still around, it’s likely they would’ve shared their experiences as grandparents.

“Diana and I had the same complete love for children. We both loved nothing more than to put a smile on a child’s face”. 

“We’d be having granny parties together and having a great time. I wonder whether there would be room for the kids to get onto the bouncy castle, as she and I would be the first on.”

Prince Harry has pulled out all the stops and ordered a bespoke birthday cake for Meghan Markle’s 40th.

The posh bakery can charge anywhere from £160 plus for cakes, with their spciality being ‘naked’ cakes where some of the cake’s layers are visible underneath the icing.

Before the showstopper will make its appearance, it’s reported that guests will enjoy “grazing tables” with locally sourced foods and wines.

The guest list for her birthday has yet to be fully revealed, but it is expected that her mum Doria and close pal Oprah will be there.

In an explosive interview earlier this year, the Duchesses dad criticized the couple’s “bad behavior” and the effect it has had on raising their son Archie and newborn girl Lilibet.

The former Hollywood lighting director has yet to meet his two grandkids.

QUEEN LAUNCHES RANGE OF DOG BISCUITS FLAVOURED WITH ROYAL VENISON

Her Majesty’s Game Bones snacks are made with game from the Sandringham estate in Norfolk and baked nearby.

They come in a paper bag with a royal seal and are additive and preservative free.

The packaging describes them as a tasty occasional treat and as a training aid. They cost £4.99 a bag.

Luxury £50 pet beds and £30 leather collars are also available from the Queen’s shop at Sandringham.

The 95-year-old monarch has owned a corgi or a dorgi, a cross between a dachshund and a corgi, since she was 18.

FIRST GLIMPSE OF LILIBET ON THE HORIZON

MEGHAN Markle could share a family photo with Lilibet to mark the proud mum’s 40th birthday in what would be the first glimpse of the eighth-in-line to the throne, royal experts have claimed.

The Duchess of Sussex and Prince Harry welcomed their daughter into the world on June 4 but the newborn baby is yet to be seen.

While working members of the Royal Family, Meghan and Harry posed with their son Archie a few days after he was born, gushing over their son’s arrival.

But royal fans are still waiting to catch a glimpse of little Lilibet, more than eight weeks since her birth on June 4.

Now royal experts have claimed Meghan’s 40th birthday tomorrow could provide the perfect opportunity for the proud parents to share an updated family photo.

Royal commentator Phil Dampier told The Sun Online: “I think it’s likely we will see a picture of the family.”

MEGHAN’S FAMILY WON’T BE SENDING HER BIRTHDAY PRESENTS AS RIFT CONTINUES, AUTHOR SAYS

The Duchess of Sussex celebrates her 40th birthday tomorrow, but it’s feared her party guest list will snub the Markle family – including her estranged dad.

Meghan has not seen her father for years, last speaking to him around the time of her wedding to Harry in 2018.

As the divide has continued to widen, Thomas recently revealed that he no longer even has his daughter’s phone number – and it’s highly unlikely he will be invited to the duchess’ birthday celebrations tomorrow.

Tom Bower, who is currently writing a tell-all book on the duchess, said: “The Sussexes’ ­celebrity neighbours, agents, lawyers and PR spin doctors will flock to their Montecito haven.

“But there will be no birthday cards from Meghan’s father and siblings, nor probably from her in-laws in London.

Shunned Thomas, who lives in Mexico, has not had any contact with his duchess daughter for three years, and he has never met her husband Harry, or their two tots, Archie and Lilibet.

PRINCE HARRY AND MEGHAN LINED UP TO MAKE HOLLYWOOD DEBUT AND PRESENT EMMY AWARD NEXT MONTH

TV execs are keen for the pair to attend the A-list event in downtown LA.

They may even try to persuade the Duke and Duchess of Sussex to present an award, insiders say.

It comes with chat show queen Oprah Winfrey the clear bookies’ favourite to take home the award for Outstanding Hosted Nonfiction Series or Special Emmy for her bombshell interview with the royal outsiders.

An LA TV source told The Sun: “The Sussexes are in high demand — it would be their first red carpet appearance since Megxit and their full-time Californian move.

“Oprah is planning to attend the night, which could help get them there."

The bombshell interview was televised in the UK on the 8 March this year. While many viewers passed Ofcom complaints and voiced their fury, Oprah insisted Meghan Markle was “truthful” in her interview and that she didn’t realise the “racist” claims would be so impactful.

In the revealing chat aired in March, Meghan told how her mental health had suffered during her time as a working royal – and she felt suicidal while pregnant with Archie.

Meanwhile, Harry said his dad and brother were “trapped” in the Royal firm and that one member of the Royal Family had probed the duke about his unborn son and what colour his skin would be.

‘AMBITIOUS’ MEGHAN MARKLE LOOKING TO TAKE OPRAH’S CROWN

According to the Mirror, A PR expert believes there is still a lot Meghan Markle wants to achieve, making she’s got her sights set on bigger things after her 40th birthday.

It ‘wouldn’t be surprising’ if Meghan has set her sights on achieving even bigger things.

Andy Barr told Closer Magazine that: “Meghan is 100 per cent the driving force behind this power couple – she has a lot of ambition and a lot she wants to achieve.

MEGHAN MARKLE ‘BORED OUT OF HER MIND BY ROYALS BALMORAL TRIP, SAYS EXPERT

Phil Dampier claimed that the Duchess of Sussex is focused on a “full-on Hollywood” life as she reaches her milestone 40th birthday tomorrow.

Phil told Fabulous: “Harry and Meghan certainly won’t miss going to Balmoral as a guest of the Queen.

“They would have been bored out of their minds and found it stifling.”

It has been reported that Meghan is hiring Oprah Winfrey's party planner for her 40th birthday bash which will host 65 and not break Covid rules.

The Duchess of Sussex has reportedly tasked Colin Cowie with planning the milestone birthday at her and Harry's £11million mansion in Santa Barbara, California.

IS IT LOVE AT FIRST SIGHT?

When it comes to remembering about matters close to the heart, Kate Middleton is quick to recall her awkward first meeting with Prince William… but he can’t remember it!

The Duchess admitted that when she met Wills for the first time at university in St Andrews in Scotland – her reaction was less than cool.

“I actually went bright red when I met you and scuttled off feeling very shy about meeting you,” she said.

Although it wasn’t quite love at first sight as the two became good friends before dating, William admitted he and Kate, “did split up for a bit. We were both very young, it was at university and we were both finding ourselves and being different characters and stuff.”

However, all that starts well ends well as Prince William and Kate Middleton tied the knot in 2011 after eight years together. 

They celebrated 10 years together in April this year.

BLOOM HITS BACK AT COMPLAINTS ABOUT HBO’S THE PRINCE MOCKING ROYAL FAMILY

ORLANDO Bloom has hit back at scathing criticism of his new TV series The Prince, which has been branded "shameful" for its portrayal of the Royal Family.

The satire hit HBO Max last month, with the Pirates Of The Caribbean actor, 44, playing the role of Prince Harry.

The show's 12 episodes are in cartoon form but already attracted hugely negative publicity for their portrayal of the late Prince Philip, and his failing health before his death.

In an interview with the Hollywood Reporter, the Brit said: "I hadn’t met [Prince Harry] when I signed up to do it, and I subsequently met him and he’s such a nice guy.

"This guy is so nice, and I think he’s got a great sense of humour.

"I hope he maintains that through this because they’re sort of on a pedestal.

"We’re showing real adoration to them in one form or another. I try to justify it, because quite frankly, if I’m honest, it’s not like me to poke fun at anyone but it is done with affection.

"When I was in my mid-20s, there was so many different people poking fun at me and, in a way, it’s a sign of appreciation."

Kate Middleton and Prince William have reportedly taken their kids on a secret holiday to the Isles of Scilly in Cornwall.

Hello! has revealed today that the family have spent the past three weeks completely off the grid. Quietly sneaking their children Prince George, Princess Charlotte, and Prince Louis away, Hello! reports they’re spending some well-deserved time together in Cornwall.

It’s not the first time they’ve visited the Isles, as Kate, William, and the kids spent their vacation there last year too.

The Isles of Scilly are reachable by air (by aircraft or helicopter) and ferry, with them being known for its beautiful beaches and picturesque scenery.

HOME IS WHERE THE HEART IS: INSIDE THE QUEEN’S SCOTLAND HOLIDAY

The Queen’s annual summer holiday began in late July this year as she departed from Windsor Castle for her Scottish retreat of Balmoral Castle.

The trip usually lasts for around three months, with Her Majesty departing in either September or early October.

No doubt the holiday will be be tainted with sadness, as it’s her first without her beloved husband Prince Phillip, who died earlier this year in April.

Every year, the Queen and her extended royal family head to Scotland to enjoy the holidays.

Her Majesty has spent a 12-week break at her special Highlands retreat Balmoral every summer of her 69-year reign. Last month, the monarch made her first trip away from Windsor since Prince Philip’s death.

It is claimed that Meghan first visited the pad in 2017, but her first official visit came after her 2018 royal wedding.

MEGHAN MARKLE ‘WOULD BE “BORED OUT OF HER MIND” BY ROYALS’ SUMMER HOLIDAY TO BALMORAL THIS YEAR’

Royal author Phil Dampier claims the Duchess of Sussex is focused on a “full-on Hollywood” life as she reaches her milestone 40th birthday tomorrow.

In fact, it’s so much so that Phil told Fabulous: “Harry and Meghan certainly won’t miss going to Balmoral as a guest of the Queen.”

Meghan will definitely be preoccupied with getting her party right. “They have very much gone full on California and won’t worry about how it looks back in the UK”.

“She is very much free to do what she wants and I’m sure they will.”

Another royal expert, Richard Fitzwilliams, told The Sun he was ‘sure’ the Royal family “will be in touch with Meghan. They will wish her ‘Happy Birthday’.

“They normally do so for birthdays.

“But I wouldn’t know if they’d send anything and it’s unlikely that we will find out.

“We wouldn’t be told if anything special will be sent.”

There are fears that the growing divide between Harry and his brother may never be fixed as William finds it “impossible to trust him again”, pals fear.

But with Meghan blowing out 40 ­candles on her birthday cake on Wednesday, it’s expected that the very public fall-out will briefly be put to one side.

MEGHAN MARKLE ‘LIKELY TO SHARE FAMILY PHOTO WITH LILIBET’ FOR HER 40TH BIRTHDAY IN FIRST GLIMPSE OF DAUGHTER

Meghan could share a family photo with Lilibet to mark the proud mum’s 40th birthday in what would be the first glimpse of the eighth-in-line to the throne, royal experts have claimed.

The Duchess of Sussex and Prince Harry welcomed their daughter into the world on June 4 but the newborn baby is yet to be seen.

With Meghan’s 40th tomorrow, it could provide the perfect opportunity for the proud parents to share an updated family photo.

Royal commentator Phil Dampier told The Sun Online: “I think it’s likely we will see a picture of the family.

ROYALS ‘TO SHARE MEGHAN MARKLE 40TH BIRTHDAY MESSAGE “THROUGH GRITTED TEETH”’

An expert has claimed today that the Royals are expected to share a birthday message to Meghan Markle to mark her 40th “through gritted teeth”. It has been said they don’t want to make the rift worse.

Despite Meghan and Harry quitting the Firm more than a year ago and starting a new life in the US before unleashing a string of allegations against the Royals, Meghan will still receive a birthday message.

Royal commentator Phil Dampier told the Sun Online: “But whether a present will be sent privately, I don’t know, such is the state of the relationship.

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One MASSIVE mistake means Meghan & Harry have 'no more currency remaining'

KSAT 12 03 August, 2021 - 06:01pm

We pay for your stories and videos

Get more from us at The Sun

Since leaving the UK last year, the Duke and Duchess of Sussex have been in the media spotlight, securing lucrative deals with the likes of Apple TV, Netflix and Spotify - the first of which was their bombshell Oprah interview.

Harry also recently announced a £29m publishing deal to release a series of memoirs - further converting the couple's "currency" as members of the royal family into million-pound mega-deals.

But Vanity Fair's royal editor Katie Nicholl has now questioned what the Sussexes' would have left to trade after these ventures come to an end.

She told the True Royalty TV: "I think the biggest threat to Harry and Meghan, once these book deals are done and the podcasts are done and Spotify, then what is their currency?"

ROYALS ‘TO SHARE MEGHAN MARKLE 40TH BIRTHDAY MESSAGE “THROUGH GRITTED TEETH”’

An expert has claimed today that the Royals are expected to share a birthday message to Meghan Markle to mark her 40th “through gritted teeth”. It has been said they don’t want to make the rift worse.

Despite Meghan and Harry quitting the Firm more than a year ago and starting a new life in the US before unleashing a string of allegations against the Royals, Meghan will still receive a birthday message.

Royal commentator Phil Dampier told the Sun Online: “But whether a present will be sent privately, I don’t know, such is the state of the relationship.

MEGHAN MARKLE ‘BORED OUT OF HER MIND BY ROYALS BALMORAL TRIP, SAYS EXPERT

Phil Dampier claimed that the Duchess of Sussex is focused on a “full-on Hollywood” life as she reaches her milestone 40th birthday tomorrow.

Phil told Fabulous: “Harry and Meghan certainly won’t miss going to Balmoral as a guest of the Queen.

“They would have been bored out of their minds and found it stifling.”

It has been reported that Meghan is hiring Oprah Winfrey’s party planner for her 40th birthday bash which will host 65 and not break Covid rules.

The Duchess of Sussex has reportedly tasked Colin Cowie with planning the milestone birthday at her and Harry’s £11million mansion in Santa Barbara, California.

THE ONE WORD KATE MIDDLETON’S NANNY IS BANNED FROM SAYING

Maria Borrallo trained at the prestigious Norland College in Bath, and as part of her training she was instructed not to say one word in particular.

Norland expert Louise Heren, and author of Nanny in a Book, discovered that there is one word Maria must not say on the job.

Speaking to the Mirror, Louise explained that that Norland nannies are banned from saying ‘kids’ and must instead use the children’s names at all times.

Louise says: “The word kid is banned. It's a mark of respect for the children as individuals.”

BLOOM HITS BACK AT COMPLAINTS ABOUT HBO’S THE PRINCE MOCKING ROYAL FAMILY

ORLANDO Bloom has hit back at scathing criticism of his new TV series The Prince, which has been branded “shameful” for its portrayal of the Royal Family.

The satire hit HBO Max last month, with the Pirates Of The Caribbean actor, 44, playing the role of Prince Harry.

The show’s 12 episodes are in cartoon form but already attracted hugely negative publicity for their portrayal of the late Prince Philip, and his failing health before his death.

In an interview with the Hollywood Reporter, the Brit said: “I hadn’t met [Prince Harry] when I signed up to do it, and I subsequently met him and he’s such a nice guy.

“This guy is so nice, and I think he’s got a great sense of humour.

“I hope he maintains that through this because they’re sort of on a pedestal.

“We’re showing real adoration to them in one form or another. I try to justify it, because quite frankly, if I’m honest, it’s not like me to poke fun at anyone but it is done with affection.

“When I was in my mid-20s, there was so many different people poking fun at me and, in a way, it’s a sign of appreciation.”

FIRST LOOK AT IMELDA STAUNTON AS THE QUEEN ON SET OF THE CROWN SEASON 5

FERGIE SAYS SHE AND DIANA WOULD HAVE BEEN ‘PARTY GRANNIES’ AND ‘FIRST ON THE BOUNCY CASTLE’

Sarah Ferguson gushed in an interview with Bella magazine after recalling her friendship with Princess Diana. She said if Princess Diana was still around, it’s likely they would’ve shared their experiences as grandparents.

“Diana and I had the same complete love for children. We both loved nothing more than to put a smile on a child’s face”. 

“We’d be having granny parties together and having a great time. I wonder whether there would be room for the kids to get onto the bouncy castle, as she and I would be the first on.”

Prince Harry has pulled out all the stops and ordered a bespoke birthday cake for Meghan Markle’s 40th.

The posh bakery can charge anywhere from £160 plus for cakes, with their spciality being ‘naked’ cakes where some of the cake’s layers are visible underneath the icing.

Before the showstopper will make its appearance, it’s reported that guests will enjoy “grazing tables” with locally sourced foods and wines.

The guest list for her birthday has yet to be fully revealed, but it is expected that her mum Doria and close pal Oprah will be there.

In an explosive interview earlier this year, the Duchesses dad criticized the couple’s “bad behavior” and the effect it has had on raising their son Archie and newborn girl Lilibet.

The former Hollywood lighting director has yet to meet his two grandkids.

QUEEN LAUNCHES RANGE OF DOG BISCUITS FLAVOURED WITH ROYAL VENISON

Her Majesty’s Game Bones snacks are made with game from the Sandringham estate in Norfolk and baked nearby.

They come in a paper bag with a royal seal and are additive and preservative free.

The packaging describes them as a tasty occasional treat and as a training aid. They cost £4.99 a bag.

Luxury £50 pet beds and £30 leather collars are also available from the Queen’s shop at Sandringham.

The 95-year-old monarch has owned a corgi or a dorgi, a cross between a dachshund and a corgi, since she was 18.

FIRST GLIMPSE OF LILIBET ON THE HORIZON

MEGHAN Markle could share a family photo with Lilibet to mark the proud mum’s 40th birthday in what would be the first glimpse of the eighth-in-line to the throne, royal experts have claimed.

The Duchess of Sussex and Prince Harry welcomed their daughter into the world on June 4 but the newborn baby is yet to be seen.

While working members of the Royal Family, Meghan and Harry posed with their son Archie a few days after he was born, gushing over their son’s arrival.

But royal fans are still waiting to catch a glimpse of little Lilibet, more than eight weeks since her birth on June 4.

Now royal experts have claimed Meghan’s 40th birthday tomorrow could provide the perfect opportunity for the proud parents to share an updated family photo.

Royal commentator Phil Dampier told The Sun Online: “I think it’s likely we will see a picture of the family.”

MEGHAN’S FAMILY WON’T BE SENDING HER BIRTHDAY PRESENTS AS RIFT CONTINUES, AUTHOR SAYS

The Duchess of Sussex celebrates her 40th birthday tomorrow, but it’s feared her party guest list will snub the Markle family – including her estranged dad.

Meghan has not seen her father for years, last speaking to him around the time of her wedding to Harry in 2018.

As the divide has continued to widen, Thomas recently revealed that he no longer even has his daughter’s phone number – and it’s highly unlikely he will be invited to the duchess’ birthday celebrations tomorrow.

Tom Bower, who is currently writing a tell-all book on the duchess, said: “The Sussexes’ ­celebrity neighbours, agents, lawyers and PR spin doctors will flock to their Montecito haven.

“But there will be no birthday cards from Meghan’s father and siblings, nor probably from her in-laws in London.

Shunned Thomas, who lives in Mexico, has not had any contact with his duchess daughter for three years, and he has never met her husband Harry, or their two tots, Archie and Lilibet.

PRINCE HARRY AND MEGHAN LINED UP TO MAKE HOLLYWOOD DEBUT AND PRESENT EMMY AWARD NEXT MONTH

TV execs are keen for the pair to attend the A-list event in downtown LA.

They may even try to persuade the Duke and Duchess of Sussex to present an award, insiders say.

It comes with chat show queen Oprah Winfrey the clear bookies’ favourite to take home the award for Outstanding Hosted Nonfiction Series or Special Emmy for her bombshell interview with the royal outsiders.

An LA TV source told The Sun: “The Sussexes are in high demand — it would be their first red carpet appearance since Megxit and their full-time Californian move.

“Oprah is planning to attend the night, which could help get them there."

The bombshell interview was televised in the UK on the 8 March this year. While many viewers passed Ofcom complaints and voiced their fury, Oprah insisted Meghan Markle was “truthful” in her interview and that she didn’t realise the “racist” claims would be so impactful.

In the revealing chat aired in March, Meghan told how her mental health had suffered during her time as a working royal – and she felt suicidal while pregnant with Archie.

Meanwhile, Harry said his dad and brother were “trapped” in the Royal firm and that one member of the Royal Family had probed the duke about his unborn son and what colour his skin would be.

‘AMBITIOUS’ MEGHAN MARKLE LOOKING TO TAKE OPRAH’S CROWN

According to the Mirror, A PR expert believes there is still a lot Meghan Markle wants to achieve, making she’s got her sights set on bigger things after her 40th birthday.

It ‘wouldn’t be surprising’ if Meghan has set her sights on achieving even bigger things.

Andy Barr told Closer Magazine that: “Meghan is 100 per cent the driving force behind this power couple – she has a lot of ambition and a lot she wants to achieve.

MEGHAN MARKLE ‘BORED OUT OF HER MIND BY ROYALS BALMORAL TRIP, SAYS EXPERT

Phil Dampier claimed that the Duchess of Sussex is focused on a “full-on Hollywood” life as she reaches her milestone 40th birthday tomorrow.

Phil told Fabulous: “Harry and Meghan certainly won’t miss going to Balmoral as a guest of the Queen.

“They would have been bored out of their minds and found it stifling.”

It has been reported that Meghan is hiring Oprah Winfrey's party planner for her 40th birthday bash which will host 65 and not break Covid rules.

The Duchess of Sussex has reportedly tasked Colin Cowie with planning the milestone birthday at her and Harry's £11million mansion in Santa Barbara, California.

IS IT LOVE AT FIRST SIGHT?

When it comes to remembering about matters close to the heart, Kate Middleton is quick to recall her awkward first meeting with Prince William… but he can’t remember it!

The Duchess admitted that when she met Wills for the first time at university in St Andrews in Scotland – her reaction was less than cool.

“I actually went bright red when I met you and scuttled off feeling very shy about meeting you,” she said.

Although it wasn’t quite love at first sight as the two became good friends before dating, William admitted he and Kate, “did split up for a bit. We were both very young, it was at university and we were both finding ourselves and being different characters and stuff.”

However, all that starts well ends well as Prince William and Kate Middleton tied the knot in 2011 after eight years together. 

They celebrated 10 years together in April this year.

BLOOM HITS BACK AT COMPLAINTS ABOUT HBO’S THE PRINCE MOCKING ROYAL FAMILY

ORLANDO Bloom has hit back at scathing criticism of his new TV series The Prince, which has been branded "shameful" for its portrayal of the Royal Family.

The satire hit HBO Max last month, with the Pirates Of The Caribbean actor, 44, playing the role of Prince Harry.

The show's 12 episodes are in cartoon form but already attracted hugely negative publicity for their portrayal of the late Prince Philip, and his failing health before his death.

In an interview with the Hollywood Reporter, the Brit said: "I hadn’t met [Prince Harry] when I signed up to do it, and I subsequently met him and he’s such a nice guy.

"This guy is so nice, and I think he’s got a great sense of humour.

"I hope he maintains that through this because they’re sort of on a pedestal.

"We’re showing real adoration to them in one form or another. I try to justify it, because quite frankly, if I’m honest, it’s not like me to poke fun at anyone but it is done with affection.

"When I was in my mid-20s, there was so many different people poking fun at me and, in a way, it’s a sign of appreciation."

Kate Middleton and Prince William have reportedly taken their kids on a secret holiday to the Isles of Scilly in Cornwall.

Hello! has revealed today that the family have spent the past three weeks completely off the grid. Quietly sneaking their children Prince George, Princess Charlotte, and Prince Louis away, Hello! reports they’re spending some well-deserved time together in Cornwall.

It’s not the first time they’ve visited the Isles, as Kate, William, and the kids spent their vacation there last year too.

The Isles of Scilly are reachable by air (by aircraft or helicopter) and ferry, with them being known for its beautiful beaches and picturesque scenery.

HOME IS WHERE THE HEART IS: INSIDE THE QUEEN’S SCOTLAND HOLIDAY

The Queen’s annual summer holiday began in late July this year as she departed from Windsor Castle for her Scottish retreat of Balmoral Castle.

The trip usually lasts for around three months, with Her Majesty departing in either September or early October.

No doubt the holiday will be be tainted with sadness, as it’s her first without her beloved husband Prince Phillip, who died earlier this year in April.

Every year, the Queen and her extended royal family head to Scotland to enjoy the holidays.

Her Majesty has spent a 12-week break at her special Highlands retreat Balmoral every summer of her 69-year reign. Last month, the monarch made her first trip away from Windsor since Prince Philip’s death.

It is claimed that Meghan first visited the pad in 2017, but her first official visit came after her 2018 royal wedding.

MEGHAN MARKLE ‘WOULD BE “BORED OUT OF HER MIND” BY ROYALS’ SUMMER HOLIDAY TO BALMORAL THIS YEAR’

Royal author Phil Dampier claims the Duchess of Sussex is focused on a “full-on Hollywood” life as she reaches her milestone 40th birthday tomorrow.

In fact, it’s so much so that Phil told Fabulous: “Harry and Meghan certainly won’t miss going to Balmoral as a guest of the Queen.”

Meghan will definitely be preoccupied with getting her party right. “They have very much gone full on California and won’t worry about how it looks back in the UK”.

“She is very much free to do what she wants and I’m sure they will.”

Another royal expert, Richard Fitzwilliams, told The Sun he was ‘sure’ the Royal family “will be in touch with Meghan. They will wish her ‘Happy Birthday’.

“They normally do so for birthdays.

“But I wouldn’t know if they’d send anything and it’s unlikely that we will find out.

“We wouldn’t be told if anything special will be sent.”

There are fears that the growing divide between Harry and his brother may never be fixed as William finds it “impossible to trust him again”, pals fear.

But with Meghan blowing out 40 ­candles on her birthday cake on Wednesday, it’s expected that the very public fall-out will briefly be put to one side.

MEGHAN MARKLE ‘LIKELY TO SHARE FAMILY PHOTO WITH LILIBET’ FOR HER 40TH BIRTHDAY IN FIRST GLIMPSE OF DAUGHTER

Meghan could share a family photo with Lilibet to mark the proud mum’s 40th birthday in what would be the first glimpse of the eighth-in-line to the throne, royal experts have claimed.

The Duchess of Sussex and Prince Harry welcomed their daughter into the world on June 4 but the newborn baby is yet to be seen.

With Meghan’s 40th tomorrow, it could provide the perfect opportunity for the proud parents to share an updated family photo.

Royal commentator Phil Dampier told The Sun Online: “I think it’s likely we will see a picture of the family.

ROYALS ‘TO SHARE MEGHAN MARKLE 40TH BIRTHDAY MESSAGE “THROUGH GRITTED TEETH”’

An expert has claimed today that the Royals are expected to share a birthday message to Meghan Markle to mark her 40th “through gritted teeth”. It has been said they don’t want to make the rift worse.

Despite Meghan and Harry quitting the Firm more than a year ago and starting a new life in the US before unleashing a string of allegations against the Royals, Meghan will still receive a birthday message.

Royal commentator Phil Dampier told the Sun Online: “But whether a present will be sent privately, I don’t know, such is the state of the relationship.

PRINCE WILLIAM AND KATE MIDDLETON’S ‘CONCERNS’ ABOUT PRINCE GEORGE GROWING UP IN SPOTLIGHT

While the Duke and Duchess of Cambridge spend a lot of time in front of the cameras, it’s their children that often steal the limelight.

As their children are growing up and becoming more of a focus for the paparazzi, the parents are concerned about online trolls. George’s appearance at the Euro final with his parents sparked a wave of online trolling.

“He’s growing up in a different era to his parents. Times have changed since then. There wasn’t social media or internet trolls when William and Kate were children.”

“The Cambridges feel it’s necessary to shield George, Charlotte and Louis from the spotlight and have become cautious about the appearances [they] make. Kate and William are being more selective about the events he attends.”

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New Fortnite gun can pick up objects and hurl them at other players

Global News 03 August, 2021 - 09:11am

This new gun is called the Grab-itron, and it's available in Fortnite Battle Royale right now thanks to patch v17.30. Chiefly, this new gun made from alien technology can be used to pick up any item you can see in front of you, from a trash can to a car, and then carry it around with you until you want to throw it at an opponent.

The item will deal more damage to opponents depending on three different factors. Firstly, the damage will factor in what the objective itself is made from, for example metal or wood, and it'll then take into account how big the object is, with larger objects dealing increased damage. Finally, the faster an object is thrown at an opponent, the bigger damage it deals to them on impact.

This Grab-itron gun has the potential to be an absolute game-changer in Fortnite. Not only can you pick up cars and throw them across the island battlefield, but you can also hold larger objects in front of you to temporarily act as a defensive barrier against incoming enemy fire.

You can even use the Grab-itron to catch enemy explosives, and then throw them back at enemy players before they detonate. You can find the brand new weapon in chests, on top of Abductors, or within the alien Mothership itself, once you've downloaded the new patch v17.30 on any platform.

Fortnite patch notes | Fortnite tips | Fortnite Creative codes | Fortnite 2FA | How to enable cross platform Fortnite matches | How to level up fast in Fortnite | How to get free Fortnite V-Bucks | Fortnite Starter Pack | Fortnite map | Fortnite new weapons | Fortnite Season 8 | Fortnite characters | Fortnite quests | Fortnite gold bars 

GamesRadar+ is part of Future US Inc, an international media group and leading digital publisher. Visit our corporate site.

© Future US, Inc. 11 West 42nd Street, 15th Floor, New York, NY 10036.

New Fortnite gun can pick up objects and hurl them at other players

Yahoo News 03 August, 2021 - 09:11am

This new gun is called the Grab-itron, and it's available in Fortnite Battle Royale right now thanks to patch v17.30. Chiefly, this new gun made from alien technology can be used to pick up any item you can see in front of you, from a trash can to a car, and then carry it around with you until you want to throw it at an opponent.

The item will deal more damage to opponents depending on three different factors. Firstly, the damage will factor in what the objective itself is made from, for example metal or wood, and it'll then take into account how big the object is, with larger objects dealing increased damage. Finally, the faster an object is thrown at an opponent, the bigger damage it deals to them on impact.

This Grab-itron gun has the potential to be an absolute game-changer in Fortnite. Not only can you pick up cars and throw them across the island battlefield, but you can also hold larger objects in front of you to temporarily act as a defensive barrier against incoming enemy fire.

You can even use the Grab-itron to catch enemy explosives, and then throw them back at enemy players before they detonate. You can find the brand new weapon in chests, on top of Abductors, or within the alien Mothership itself, once you've downloaded the new patch v17.30 on any platform.

Fortnite patch notes | Fortnite tips | Fortnite Creative codes | Fortnite 2FA | How to enable cross platform Fortnite matches | How to level up fast in Fortnite | How to get free Fortnite V-Bucks | Fortnite Starter Pack | Fortnite map | Fortnite new weapons | Fortnite Season 8 | Fortnite characters | Fortnite quests | Fortnite gold bars 

GamesRadar+ is part of Future US Inc, an international media group and leading digital publisher. Visit our corporate site.

© Future US, Inc. 11 West 42nd Street, 15th Floor, New York, NY 10036.

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